| Rank | Movie | Weekend | Theaters | Average | Total | Budget |
| 1 | Knowing | $24.8 mil | 3,332 | $7,447 | $24.8 mil | ---- |
| 2 | I Love You, Man | $18.0 mil | 2,711 | $6,641 | $18.0 mil | ---- |
| 3 | Duplicity | $14.4 mil | 2,574 | $5,595 | $14.4 mil | ---- |
| 4 | Race to Witch Mountain | $13.0 mil | 3,187 | $4,080 | $44.7 mil | ---- |
| 5 | Watchmen | $6.7 mil | 3,510 | $1,916 | $98.0 mil | $150 |
| 6 | The Last House on the Left | $5.9 mil | 2,402 | $2,465 | $24.0 mil | ---- |
| 7 | Taken | $4.1 mil | 2,661 | $1,541 | $133.1 mil | ---- |
| 8 | Slumdog Millionaire | $2.7 mil | 2,067 | $1,306 | $137.2 mil | $15 |
| 9 | Tyler Perry’s Madea Goes to Jail | $2.5 mil | 1,835 | $1,368 | $87.2 mil | ---- |
| 10 | Coraline | $2.1 mil | 1,431 | $1,498 | $72.8 mil | ---- |