| Rank | Movie | Weekend | Theaters | Average | Total | Budget |
| 1 | Up | $68.2 mil | 3,766 | $18,109 | $68.2 mil | ---- |
| 2 | Night at the Museum 2 | $25.5 mil | 4,101 | $6,218 | $105.2 mil | $150 |
| 3 | Drag Me to Hell | $16.6 mil | 2,508 | $6,630 | $16.6 mil | ---- |
| 4 | Terminator Salvation | $16.1 mil | 3,602 | $4,481 | $90.6 mil | $200 |
| 5 | Star Trek | $12.8 mil | 3,507 | $3,650 | $209.5 mil | $165 |
| 6 | Angels & Demons | $11.2 mil | 3,464 | $3,233 | $104.7 mil | $150 |
| 7 | Dance Flick | $4.9 mil | 2,459 | $1,993 | $19.2 mil | $25 |
| 8 | X-Men Origins: Wolverine | $3.9 mil | 2,263 | $1,723 | $170.8 mil | $150 |
| 9 | Ghosts of Girlfriends Past | $1.9 mil | 1,450 | $1,314 | $50.0 mil | ---- |
| 10 | Obsessed | $665,000 | 679 | $979 | $67.5 mil | $20 |