| Rank | Movie | Weekend | Theaters | Average | Total | Budget |
| 1 | Transformers 2 | $42.3 mil | 4,234 | $9,995 | $293.4 mil | $200 |
| 2 | Ice Age 3 | $41.6 mil | 4,099 | $10,171 | $66.7 mil | $90 |
| 3 | Public Enemies | $25.2 mil | 3,334 | $7,580 | $40.1 mil | $100 |
| 4 | The Proposal | $12.8 mil | 3,099 | $4,149 | $94.3 mil | $40 |
| 5 | The Hangover | $11.2 mil | 3,070 | $3,630 | $205.0 mil | $35 |
| 6 | Up | $6.5 mil | 2,656 | $2,477 | $264.8 mil | $175 |
| 7 | My Sister’s Keeper | $5.7 mil | 2,606 | $2,221 | $26.5 mil | $30 |
| 8 | The Taking of Pelham 123 | $2.5 mil | 1,908 | $1,310 | $58.4 mil | $100 |
| 9 | Year One | $2.3 mil | 2,240 | $1,037 | $38.3 mil | $150 |
| 10 | Night at the Museum 2 | $2.0 mil | 1,419 | $1,440 | $167.7 mil | $60 |