Claire Redfield(Ali Larter) appears in RESIDENT EVIL: EXTINCTION(2007).
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Update: Milla Out, Ali Larter in For RESIDENT EVIL 4?

 While attending the premiere of RESIDENT EVIL: EXTINCTION, Ryan Rotten has posed the question of the franchise going onward even if the Alice storyline seems to be wrapping up. Actress Ali Larter has hinted that's definitely a possibility from what she's hearing. If the third installment is a success in the box office, the franchise of films may continue onward focusing on the character of Claire Redfield(portrayed by Larter).

Actress Ali Larter says she has "heard whispers" of a fourth "Resident Evil" film. The next chapter may spin off from the Alice arc and instead focus on Claire Redfield. "We'll see come Monday, right?"

It seems to fit. Claire is a character from the games and we could see sequels/prequels dealing with her brother Chris Redfield (another major character from the gaming franchise). Still, it depends on how well this installment does at the box office this weekend.

Update: Leading into some interesting questions about Alice's (Milla Jovovich) character having an open-ended possibility in the fourth film being mentioned above, I checked with  Mr. Miska over at Bloody Disgusting and other sources around the net. Apparently, Milla has confirmed this will be her final appearance as Alice in the Resident Evil franchise at the premiere for the film. She's also hinted alongside Ali Larter that there may be a spin-off with Claire Redfield which as mentioned above, is based off a character in the video game series.

So, Milla is out from what she's telling various reporters, Ali is possibly in..

When more information comes, I'll pass it along..